منابع مشابه
T Cell Vaccination as a Tool in the Treatment of Collagen Induced Arthritis in Albino Rats
Background: The effectiveness of T cell vaccination has been demonstrated in a variety of animal models of both induced and spontaneous autoimmune diseases. Objective: The purpose of this study was to test the T cell vaccination protocol to treat and prevent collagen induced arthritis (CIA) in a rheumatoid arthritis model. Methods: CIA was induced by an intradermal injection of an artheritogen ...
متن کاملT cell vaccination : An insight into T cell regulation
Here we review T cell vaccination (TCV), a cell-based, generic approach to immune regulation. We describe TCV clinical trials in multiple sclerosis and other autoimmune diseases; we analyze the immune regulatory mechanisms activated by TCV; we examine the potential of public T cells as TCV mediators, and we discuss the physiology of immune regulation in the light of TCV.
متن کاملt cell vaccination as a tool in the treatment of collagen induced arthritis in albino rats
background: the effectiveness of t cell vaccination has been demonstrated in a variety of animal models of both induced and spontaneous autoimmune diseases. objective: the purpose of this study was to test the t cell vaccination protocol to treat and prevent collagen induced arthritis (cia) in a rheumatoid arthritis model. methods: cia was induced by an intradermal injection of an artheritogen ...
متن کاملVaccination in humans generates broad T cell cytokine responses.
In recent years, the quantification of T cell responses to pathogens or immunogens has become a common tool in the evaluation of disease pathogenesis or vaccine immunogenicity. Such measurements are usually limited to enumerating IFN-gamma-producing cells after ex vivo stimulation with Ag, but little is known about the phenotype or complete functional repertoire of the Ag-specific cells. We use...
متن کاملTregs in T cell vaccination: exploring the regulation of regulation.
T cell vaccination (TCV) activates Tregs of 2 kinds: anti-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4+ and CD8+ Tregs have been described in detail. Here we shall focus on anti-erg...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2020
ISSN: 0952-7915
DOI: 10.1016/j.coi.2020.05.002